In collaboration with Laszlo Farkas (VCU), we showed that deficiency of the pattern recognition receptor (TLR3) exacerbated pulmonary hypertension, while activating TLR3 (using synthetic double-stranded RNA) reduced the severity of pulmonary hypertension in animal models of the disease. I also worked on host pathogen interactions in hypoxia and demonstrated that ambient hypoxia adversely altered the host response to a limited bacterial challenge, provoking a profound phenotype of systemic illness including cardiovascular dysfunction.Īligning my research interests with my clinical interest in pulmonary arterial hypertension (a devastating disease characterised by progressive remodelling of pulmonary blood vessels), my postdoctoral research has focussed on the role of inflammation and hypoxia in this condition. In 20 I organised two successful high altitude research expeditions to Bolivia, focusing on maladaptive responses to hypoxia that can result in altitude illness ( During my PhD, I broadened my interests into the field of cell biology, specifically the role of HIF-2alpha in neutrophilic inflammation. Hypoxia has been the general theme of my research interests. I am now a Senior Clinical Lecturer in Respiratory Medicine. For 12 months from September 2017 I was a BHF-Fulbright scholar ( in Professor Marlene Rabinovitch’s lab at Stanford University and returned to Sheffield in 2018 as a BHF Intermediate Clinical Fellow. In 2016, I was appointed as a JG Graves Fellow and an Honorary Consultant in Respiratory Medicine at Sheffield Teaching Hospitals NHS Foundation Trust. I completed an MRC Training Fellowship and PhD in 2012 under the supervision of Professor Moira Whyte and Dr Sarah Walmsley before finishing my specialist clinical training as an NIHR Clinical Lecturer. Support for refugee students and scholarsįor enquiries please contact - moved to Sheffield in 2006 to take up an NIHR Academic Clinical Fellowship in Respiratory Medicine having completed my undergraduate training and a medical rotation in Edinburgh.Conferences, events, visitor accommodation and weddings.Research centres, institutes and networks. Subject taster sessions for Y12 and Y13 students.
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